Reversal of pentylenetetrazole-induced seizure activity in mice by nickel chloride
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چکیده
منابع مشابه
Reversal of pentylenetetrazole-induced seizure activity in mice by nickel chloride
OBJECTIVE The present study was designed to investigate the anticonvulsant potential of nickel which is shown to selectively block t-type calcium channels by using nickel choride on pentylenetetrazole (80 mg/kg) induced seizure activity model in mice. MATERIALS AND METHODS Seizures were assessed in terms of onset of Straub's tail phenomenon and onset of jerky movements of the whole body, conv...
متن کاملCopper sulfate inhibits seizure activity induced by pentylenetetrazole in mice
Background and Objective: Copper is one of the main micronutrients of body which plays a key role as a cofactor in the function of metabolic enzymes. Previous studies have shown that copper sulfate () inhibits long-term potentiation (LTP) in slices of hippocampal CA1 region. Whereas LTP is involved in learning and epilepsy, it seems that copper effects on LTP could be associated with its effect...
متن کاملcopper sulfate inhibits seizure activity induced by pentylenetetrazole in mice
background and objective: copper is one of the main micronutrients of body which plays a key role as a cofactor in the function of metabolic enzymes. previous studies have shown that copper sulfate () inhibits long-term potentiation (ltp) in slices of hippocampal ca1 region. whereas ltp is involved in learning and epilepsy, it seems that copper effects on ltp could be associated with its effect...
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BACKGROUND ATP sensitive potassium channels are widely distributed in central nervous system (CNS) and these channels could be the target in CNS disorders by their modulators. PURPOSE The present study was designed to investigate the anticonvulsant potential of glibenclamide on MES induced seizure and pentylenetetrazole induced seizure in mice. METHODS Seizures were induced in 7 months albi...
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Gamma-aminobutyric acid (GABA) is an important inhibitory transmitter in central nervous system and is involved in pathophysiology of epilepsy. Pentylenete-trazole (PTZ), a convulsant agent, partly acts via anion channel of GABAA receptor. Ivermectin, an antiparasitic agent and a GABAA agonist, has anticonvulsant effect in animal seizure models. Cholestasis increases ...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmacology
سال: 2009
ISSN: 0253-7613
DOI: 10.4103/0253-7613.48885